Matsuda Tetsuro, Shikata Satoru
Dept. of Surgery, Soseikai General Hospital, Japan.
Gan To Kagaku Ryoho. 2008 Mar;35(3):511-3.
A 71-year-old man underwent right hemicolectomy for an ascending colon cancer (stage II, Cur A) in September 2001. Adjuvant chemotherapy with tegafur/uracil was performed, but CT scans and FDG-PET, conducted in May 2003, revealed cancerous pleuritis and lung metastasis. Although 2 courses of the chemotherapy with LV+5-FU (RPMI regimen) were completed, progressive disease was confirmed. Therefore, the chemotherapy with CPT-11 (100 mg/ day; day 1, 15)+S-1 (100 mg/day; day 1-21) was started in May 2004. After completion of 6 courses, CT scan showed a partial response. Only grade 2 vomiting was noted as an adverse reaction to the treatment, however, the patient has been managed on an outpatient basis for the last 3 years with good QOL and the cancer under control. This case suggests that this combination therapy can be expected to be highly effective as a safe approach for continuously maintaining the QOL of patients with advanced or recurrent colorectal cancer.
一名71岁男性于2001年9月因升结肠癌（II期，A组）接受了右半结肠切除术。术后进行了替加氟/尿嘧啶辅助化疗，但2003年5月的CT扫描和FDG-PET检查显示出现癌性胸膜炎和肺转移。尽管完成了2个疗程的LV + 5-FU化疗（RPMI方案），但病情仍进展。因此，2004年5月开始使用CPT-11（100mg/天；第1、15天）+ S-1（100mg/天；第1 - 21天）进行化疗。完成6个疗程后，CT扫描显示部分缓解。治疗的不良反应仅记录到2级呕吐，然而，在过去3年里患者一直作为门诊病人接受治疗，生活质量良好，癌症病情得到控制。该病例表明，这种联合治疗有望作为一种安全的方法，对晚期或复发性结直肠癌患者的生活质量进行持续有效维持，具有高效性。
