茯苓中两种新的羊毛甾烷型三萜类化合物。

Two new lanostane triterpenoids from Poria cocos.

作者信息

Zheng Yan, Yang Xiu-Wei

机构信息

State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicine, School of Pharmaceutical Sciences, Peking University, Beijing, China.

出版信息

J Asian Nat Prod Res. 2008 Mar-Apr;10(3-4):323-8. doi: 10.1080/10286020801892250.

DOI:10.1080/10286020801892250

PMID:18348055

Abstract

Two new lanostane triterpenoids, 29-hydroxypolyporenic acid C (4) and 25-hydroxypachymic acid (5), together with three known compounds, ergosta-7,22-dien-3beta-ol (1), polyporenic acid C (2) and pachymic acid (3), were isolated from the 95% ethanolic extract of the sclerotium of Poria cocos (Schw.) Wolf. Their structures were determined by extensive spectroscopic analyses, including IR, UV, ESITOF-MS, HRESI-MS, 1D and 2D NMR data (1H NMR, 13C NMR, 1H-1H COSY, NOESY, HSQC and HMBC).

摘要

从茯苓（Poria cocos (Schw.) Wolf）菌核的95%乙醇提取物中分离得到两个新的羊毛甾烷型三萜化合物，29-羟基茯苓酸C（4）和25-羟基茯苓酸（5），以及三个已知化合物，麦角甾-7,22-二烯-3β-醇（1）、茯苓酸C（2）和茯苓酸（3）。通过广泛的光谱分析确定了它们的结构，包括红外光谱（IR）、紫外光谱（UV）、电喷雾电离飞行时间质谱（ESITOF-MS）、高分辨电喷雾电离质谱（HRESI-MS）、一维和二维核磁共振数据（1H NMR、13C NMR、1H-1H COSY、NOESY、HSQC和HMBC）。