Frieden E, Hsieh H S
Adv Exp Med Biol. 1976;74:505-29. doi: 10.1007/978-1-4684-3270-1_43.
Ceruloplasmin (ferroxidase) the blue Cu-protein of vertebrate plasma, possesses significant oxidase activity towards Fe(II) and numerous aromatic amines and phenols. Its ferroxidase activity has led to the discovery that it is a molecular link between copper and iron metabolism. Ceruloplasmin mobilizes iron into the plasma from iron storage cells in the liver. An additional role of Cp may be as a contributor to the regulation of the balance of biogenic amines through its oxidase action on the epinephrine and the hydroxyindole series. Ceruloplasmin also serves as a major copper transport vehicle, comparable to transferrin for iron. Evidence is presented that the copper atoms of Cp are a prerequisite for copper utilization in the biosynthesis of cytochrome oxidase. The ability of Cp to release copper at specific cellular sites is believed to be related to its broad substrate spectrum of biological reducing agents. Thus Cp is a serum protein with several important functions, all of which are directly related to its oxidase activity.
铜蓝蛋白（亚铁氧化酶）是脊椎动物血浆中的蓝色铜蛋白，对亚铁离子以及多种芳香胺和酚类具有显著的氧化酶活性。其亚铁氧化酶活性促使人们发现它是铜和铁代谢之间的分子纽带。铜蓝蛋白将铁从肝脏中的铁储存细胞转运到血浆中。铜蓝蛋白的另一个作用可能是通过其对肾上腺素和羟吲哚系列的氧化酶作用，参与生物胺平衡的调节。铜蓝蛋白还作为主要的铜转运载体，类似于铁的转铁蛋白。有证据表明，铜蓝蛋白中的铜原子是细胞色素氧化酶生物合成中铜利用的先决条件。铜蓝蛋白在特定细胞部位释放铜的能力被认为与其广泛的生物还原剂底物谱有关。因此，铜蓝蛋白是一种具有多种重要功能的血清蛋白，所有这些功能都与其氧化酶活性直接相关。
