Frieden E
Ciba Found Symp. 1980;79:93-124. doi: 10.1002/9780470720622.ch6.
Ceruloplasmin is a blue copper protein found in the alpha 2-globulin fraction of vertebrate plasma. It is a single-chain glycoprotein of molecular weight 132 000. It contains six copper atoms per molecule, comprising three or possibly four different types of copper. Its many functions may be related to the heterogeneous nature of these six copper atoms and to the various catalytic activities which they provide. Caeruloplasmin resembles albumin and transferrin in that all three serum proteins are regarded primarily as transport proteins. However, each has numerous other action as important as this transport function. Caeruloplasmin directly mobilizes iron into the serum and provides the major molecular link between copper and iron metabolism; it is the most prominent serum antioxidant, preventing deleterious oxidation of polyenoic acids and other substrates; it scavenges superoxide radicals; it serves as an acute-phase reactant (an endogenous modulator) of the inflammatory response; finally, caeruloplasmin may regulate the serum concentration of the biogenic amines, adrenaline (epinephrine) and serotonin (5-HT).
铜蓝蛋白是一种蓝色铜蛋白，存在于脊椎动物血浆的α2球蛋白部分。它是一种分子量为132000的单链糖蛋白。每个分子含有六个铜原子，包括三种或可能四种不同类型的铜。它的许多功能可能与这六个铜原子的异质性以及它们提供的各种催化活性有关。铜蓝蛋白类似于白蛋白和转铁蛋白，因为这三种血清蛋白主要都被视为转运蛋白。然而，它们各自还有许多与这种转运功能同样重要的其他作用。铜蓝蛋白直接将铁转运到血清中，并在铜和铁代谢之间提供主要的分子联系；它是最突出的血清抗氧化剂，可防止多不饱和脂肪酸和其他底物的有害氧化；它能清除超氧自由基；它作为炎症反应的急性期反应物（一种内源性调节剂）；最后，铜蓝蛋白可能调节生物胺、肾上腺素（肾上腺素）和血清素（5-羟色胺）的血清浓度。
