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增加应对疟疾的价值。

Grid-added value to address malaria.

作者信息

Breton V, Jacq N, Kasam V, Hofmann-Apitius M

机构信息

Laboratoire de Physique Corpusculaire de Clermond-Ferrand, Université Blaise Pascal/IN2P3-CNRS UMR 6533, 63177 Aubière Cedex, France.

出版信息

IEEE Trans Inf Technol Biomed. 2008 Mar;12(2):173-81. doi: 10.1109/TITB.2007.895930.

Abstract

Through this paper, we call for a distributed, Internet-based collaboration to address one of the worst plagues of our present world, malaria. The spirit is a nonproprietary peer-production of information-embedding goods. And we propose to use the grid technology to enable such a worldwide "open-source" like collaboration. The first step toward this vision has been achieved during the summer 2005 on the enabling grids for E-scienceE (EGEE) grid infrastructure where 42 million ligands were docked for a total amount of 80 CPU years in 6 weeks in the quest for new drugs. The impact of this first deployment has significantly raised the interest of the research community so that several laboratories all around the world expressed interest to propose targets for a second large-scale deployment against malaria.

摘要

通过本文,我们呼吁开展基于互联网的分布式协作,以应对当今世界最严重的瘟疫之一——疟疾。其精神是信息嵌入产品的非专有对等生产。并且我们提议利用网格技术来实现这种类似全球“开源”的协作。朝着这一愿景迈出的第一步已于2005年夏天在面向电子科学的启用网格(EGEE)基础设施上实现,在该设施中,为了寻找新药,在6周内对接了4200万个配体,总计使用了80个中央处理器年。首次部署的影响显著提高了研究界的兴趣,以至于世界各地的几个实验室都表示有兴趣为第二次大规模抗疟疾部署提出目标。

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