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Fluorodeoxyglucose uptake of primary non-small cell lung cancer at positron emission tomography: new contrary data on prognostic role.正电子发射断层扫描中原发性非小细胞肺癌的氟脱氧葡萄糖摄取：关于预后作用的新的相反数据。
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Predicting gene promoter methylation in non-small-cell lung cancer by evaluating sputum and serum.通过评估痰液和血清预测非小细胞肺癌中的基因启动子甲基化
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DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value.DNA甲基转移酶信使核糖核酸表达及非小细胞肺癌中CpG岛的异常甲基化：相关性及预后价值
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Analysis of repetitive element DNA methylation by MethyLight.利用甲基化荧光定量PCR技术分析重复元件DNA甲基化
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非小细胞肺癌患者肿瘤组织及配对正常组织中的DNA甲基化

DNA methylation in tumor and matched normal tissues from non-small cell lung cancer patients.

作者信息

Feng Qinghua, Hawes Stephen E, Stern Joshua E, Wiens Linda, Lu Hiep, Dong Zhao Ming, Jordan C Diana, Kiviat Nancy B, Vesselle Hubert

机构信息

Department of Pathology, School of Medicine, University of Washington, Box 357115, Seattle, WA 98195-7115, USA.

出版信息

Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):645-54. doi: 10.1158/1055-9965.EPI-07-2518.

DOI:10.1158/1055-9965.EPI-07-2518
PMID:18349282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2798850/
Abstract

We used MethyLight assays to analyze DNA methylation status of 27 genes on 49 paired cancerous and noncancerous tissue samples from non-small cell lung cancer (NSCLC) patients who underwent surgical resection. Seven genes (RARB, BVES, CDKN2A, KCNH5, RASSF1, CDH13, and RUNX) were found to be methylated significantly more frequently in tumor tissues than in noncancerous tissues. Only methylation of CCND2 and APC was frequently detected in both cancerous and noncancerous tissues, supporting the hypothesis that the methylation of these two genes is a preneoplastic change and may be associated with tobacco smoking exposure. Methylation of any one of eight genes (RASSF1, DAPK1, BVES, CDH13, MGMT, KCNH5, RARB, or CDH1) was present in 80% of NSCLC tissues but only in 14% of noncancerous tissues. Detection of methylation of these genes in blood might have utility in monitoring and detecting tumor recurrence in early-stage NSCLC after curative surgical resection.

摘要

我们采用甲基化荧光定量分析方法，对49例接受手术切除的非小细胞肺癌（NSCLC）患者的配对癌组织和癌旁组织样本中的27个基因的DNA甲基化状态进行了分析。结果发现，与癌旁组织相比，肿瘤组织中7个基因（RARB、BVES、CDKN2A、KCNH5、RASSF1、CDH13和RUNX）的甲基化频率显著更高。仅CCND2和APC的甲基化在癌组织和癌旁组织中均频繁检测到，这支持了这两个基因的甲基化是肿瘤前变化且可能与吸烟暴露相关的假设。8个基因（RASSF1、DAPK1、BVES、CDH13、MGMT、KCNH5、RARB或CDH1）中任何一个基因的甲基化存在于80%的NSCLC组织中，但仅存在于14%的癌旁组织中。检测血液中这些基因的甲基化可能有助于监测和检测根治性手术切除后早期NSCLC的肿瘤复发。