Cho Young Deok
Digestive Disease Center, Department of Internal Medicine, Soon Chun Hyang University College of Medicine, Seoul, Korea.
Korean J Gastroenterol. 2008 Feb;51(2):119-26.
Unfortunately, only a minority of patients with pancreatic cancers are suitable for resection and potential cure. Despite recent advances in systemic treatment of patients with advanced pancreatic cancer, the prognosis still remains poor. The median survival of patients in whom pancreatic cancers are surgically unresectable is 6 months. Thus, optimal palliation of symptoms to maximize remaining quality of life is of primary importance to most patients. Common problems include pain, unexplained weight loss, nausea, vomiting, streatorrhea, dyspepsia, depression, and jaundice. Management is directed at the palliation of symptoms. Treatment of patients with locally unresectable, recurrent, or metastatic disease is individualized, considering the patient age, patient wishes, family influence, and insurance constraints. Success in managing progressive symptoms is needed to palliate patients with advanced pancreatic cancer.
不幸的是,只有少数胰腺癌患者适合进行切除手术并有可能治愈。尽管晚期胰腺癌患者的全身治疗最近取得了进展,但其预后仍然很差。胰腺癌无法进行手术切除的患者的中位生存期为6个月。因此,对大多数患者来说,优化症状缓解以最大限度提高剩余生活质量至关重要。常见问题包括疼痛、不明原因的体重减轻、恶心、呕吐、脂肪泻、消化不良、抑郁和黄疸。治疗的目的是缓解症状。对于局部无法切除、复发或转移性疾病患者的治疗是个体化的,要考虑患者年龄、患者意愿、家庭影响和保险限制。需要成功控制进行性症状,以缓解晚期胰腺癌患者的症状。