Lee Valerie, Cheng Haiying, Li Guangyuan, Saif Muhammad Wasif
Columbia University Medical Center and New York Presbyterian Hospital, New York, NY 10032, USA.
JOP. 2012 Mar 10;13(2):182-4.
Pancreatic cancer is a rapidly fatal disease with palliation often serving as the main goal of treatment. The end of life is often marked by severe symptoms and poor quality of life (QoL). Several studies presented at the 2012 ASCO Gastrointestinal Cancers Symposium addressed the importance of symptom identification and management for patients with pancreatic cancer: 1) a study evaluating the correlation between patient-reported symptoms, disease burden and treatment duration in patients with advanced pancreatic cancer undergoing gemcitabine-based chemotherapy (Abstract #370); 2) a Japanese study found that patients without worsening of pain or sleep symptoms at one month of chemotherapy had higher frequency of disease control (Abstract #195); and 3) a study showed that fear of cancer recurrence is a substantial problem following resection and should be targeted (Abstract #289). The authors summarize the findings and discuss the importance of QoL in these patients. The results of these studies may facilitate in identifying symptom changes as predictive markers, and improving care and QoL for patients with this devastating disease.
胰腺癌是一种迅速致命的疾病，姑息治疗往往是主要治疗目标。生命末期通常以严重症状和低生活质量（QoL）为特征。在2012年美国临床肿瘤学会（ASCO）胃肠道癌症研讨会上发表的几项研究探讨了胰腺癌患者症状识别和管理的重要性：1）一项评估接受吉西他滨化疗的晚期胰腺癌患者自我报告症状、疾病负担和治疗持续时间之间相关性的研究（摘要#370）；2）一项日本研究发现，化疗一个月时疼痛或睡眠症状未恶化的患者疾病控制频率更高（摘要#195）；3）一项研究表明，癌症复发恐惧是切除术后的一个重大问题，应予以关注（摘要#289）。作者总结了这些研究结果，并讨论了这些患者生活质量的重要性。这些研究结果可能有助于将症状变化识别为预测指标，并改善这种毁灭性疾病患者的护理和生活质量。
