Grainger Rebecca, Taylor William J
Department of Medicine, Wellington School of Medicine & Health Sciences, University of Otago, Wellington 6242, New Zealand.
Curr Opin Rheumatol. 2008 Mar;20(2):173-8. doi: 10.1097/BOR.0b013e3282f36cf1.
Novel therapies for gout have recently been developed which has prompted considerable efforts in defining the relevant outcomes for measurement in intervention trials of gout. This review summarizes the consensus exercises refining domains for measurement and the work of individual groups in assessment of the validity of measurement tools for these domains.
Recent publications have focused on the consensus exercises and validation studies of measurement tools, particularly in relation to tophus size and imaging.
Consensus on potential outcome domains has been achieved, but measuring these domains requires further validation in observational studies and confirmation of relevance from people with gout. Further work is also required in refining measurements of tophus size and imaging scores. The role of a response criteria measure is also yet to be defined, especially in relation to reduction in flare frequency, or whether composite criteria are necessary.
近期已开发出痛风的新型疗法，这促使人们在确定痛风干预试验中相关测量结局方面付出了巨大努力。本综述总结了为完善测量领域所开展的共识性活动，以及各研究小组在评估这些领域测量工具有效性方面所做的工作。
近期的出版物主要关注测量工具的共识性活动和验证研究，尤其是在痛风石大小和成像方面。
已就潜在结局领域达成共识，但在观察性研究中测量这些领域需要进一步验证，并需得到痛风患者对其相关性的确认。在完善痛风石大小测量和成像评分方面也需要进一步开展工作。反应标准测量的作用也有待确定，尤其是在减少发作频率方面，或者是否需要综合标准。
