Bjertness E
Avdeling for Samfunnsmedisin, Statens Institutt for Folkehelse, Oslo.
Nor Tannlaegeforen Tid. 1991 Aug;101(12):404-7.
It is likely that dental personnel have little knowledge about Alzheimer's disease (AD), the most common of the degenerative diseases. The number of patients with AD will increase in the future, due to an increasing number of the aged. The number of AD-patients in need of dental treatment will also increase because of a continually higher number of remaining teeth among the elderly. To meet this category of patients, it is of importance to increase the knowledge of AD. The criteria for the diagnosis of AD may be summarized as loss of intellectual accomplishment, loss of memory, slowly progressive course of the disease and either loss of abstract thinking, loss of judgement, loss of higher cortical functions or personality disturbances. The prevalence of senile dementia in Oslo has been estimated to 72% in nursing homes and 11% for the population living at home for the age group <75 years. Among these, between 50 and 70 percent suffer from AD. The etiology of AD is unknown, but the two most accepted hypotheses are the genetic and the toxic. Epidemiological and molecular biological evidence points to the possible involvement of aluminum in the aetiopathogenesis of Alzheimer's disease.
牙科人员可能对阿尔茨海默病（AD）这一最常见的退行性疾病了解甚少。由于老年人数量不断增加，未来AD患者的数量将会上升。由于老年人中存留牙齿的数量持续增多，需要牙科治疗的AD患者数量也会增加。为了应对这类患者，增加对AD的了解很重要。AD的诊断标准可概括为智力成就丧失、记忆力丧失、疾病进展缓慢以及抽象思维丧失、判断力丧失、高级皮层功能丧失或人格障碍。据估计，奥斯陆养老院中老年痴呆症的患病率在<75岁年龄组中为72%，居家生活人群中为11%。其中，50%至70%患有AD。AD的病因尚不清楚，但最被认可的两种假说是遗传假说和毒性假说。流行病学和分子生物学证据表明铝可能参与了阿尔茨海默病的发病机制。
