Rosenberg Alex
Center for Philosophy of Biology, Duke University, Durham, NC 27708, USA.
Hist Philos Life Sci. 2006;28(4):549-65.
This paper argues that nothing that has been discovered in the increasingly complex delails of gene regulation has provided any grounds to retract or qualify Crick's version of the central dogma. In particular it defends the role of the genes as the sole bearers of information, and argues that the mechanism of epigenetic modification of the DNA is but another vindication of Crick's version of the central dogma. The paper shows that arguments of C.K. Waters for the distinctive causual role of the genes are equivalent in important respects to the present ones and concludes with a defense of the informational role of the genes against an argument from trans-acting genetic regulation due to Stotz.
本文认为，在基因调控日益复杂的细节中所发现的任何内容，都没有提供任何理由来推翻或修正克里克版本的中心法则。特别是，它捍卫了基因作为信息唯一承载者的作用，并认为DNA的表观遗传修饰机制不过是对克里克版本中心法则的又一次证明。本文表明，C.K. 沃特斯关于基因独特因果作用的论点在重要方面与本文的论点相当，并以捍卫基因的信息作用来回应斯托茨关于反式作用基因调控的论点作为结论。
