Oravecz T, Monostori E, Kurucz E, Takács L, Andó I
Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, Szeged.
Scand J Immunol. 1991 Nov;34(5):531-7. doi: 10.1111/j.1365-3083.1991.tb01576.x.
In the present study we have investigated the effect of CD45, CD45RA and CD45RO monoclonal antibodies (MoAbs) on the CD3 receptor-mediated proliferation of human T lymphocytes. It is shown that CD3-induced proliferation of purified resting T cells and quiescent T lymphoblasts (QTL) is promoted via all of the investigated CD45-associated epitopes. It is also shown that the CD45 molecules are required to be cross-linked for costimulation. The MoAbs enhance the interleukin-2 (IL-2) production of CD3-stimulated QTL. The elevation of the IL-2 production correlates with the increase in CD3-induced cell proliferation suggesting that the CD45-driven regulation of T lymphocyte activation is linked to the IL-2 pathway.
在本研究中，我们研究了CD45、CD45RA和CD45RO单克隆抗体（MoAbs）对人T淋巴细胞CD3受体介导的增殖的影响。结果表明，通过所有研究的与CD45相关的表位可促进CD3诱导的纯化静止T细胞和静止T淋巴母细胞（QTL）的增殖。还表明，CD45分子需要交联才能进行共刺激。这些单克隆抗体可增强CD3刺激的QTL的白细胞介素-2（IL-2）产生。IL-2产生的升高与CD3诱导的细胞增殖增加相关，这表明CD45驱动的T淋巴细胞活化调节与IL-2途径有关。
