Lützow-Holm C
Hudavdelingen, Rikshospitalet, Oslo.
Tidsskr Nor Laegeforen. 1991 Sep 20;111(22):2739-40.
The author describes two cases of naproxene-induced bullous photodermatitis (pseudoporphyria) with recurrent blisters and fragility of the skin of hands and face. The cutaneous changes were clinically and histologically indistinguishable from those noted in porphyria cutanea tarda, but were without the associated haematological abnormalities. The lesions remitted upon the cessation of naproxene therapy. Pseudoporphyria may be considered as a phototoxic reaction to drugs or unknown chromophores and is also seen in hemodialysis patients and users of UVA-sunbeds. Naproxene-induced pseudoporphyria has not been previously reported in Norway.
作者描述了两例萘普生诱发的大疱性光性皮炎（假性卟啉症），患者手部和面部皮肤反复出现水疱且皮肤脆弱。这些皮肤变化在临床和组织学上与迟发性皮肤卟啉症所见无异，但无相关血液学异常。停用萘普生治疗后，皮损消退。假性卟啉症可被视为对药物或未知发色团的光毒性反应，在血液透析患者和使用紫外线A日光浴床的人群中也可见到。挪威此前尚未报道过萘普生诱发的假性卟啉症。
