Gold R P, Black T J, Rotterdam H, Casarella W J
AJR Am J Roentgenol. 1976 Sep;127(3):397-401. doi: 10.2214/ajr.127.3.397.
A case of a non-beta islet cell tumor of the pancreas that produced the WDHA (watery diarrhea, hypokalemia, and achlorhydria) syndrome is presented. An enlarged body-tail region of the pancreas is demonstrated on transaxial views; multiple fluid-filled loops of small and large bowel are also noted. The angiography of the tumor is similar to other non-beta islet cell lesions consisting of a large hypervascular mass with hypertrophied feeding vessels and a persistent, dense capillary stain. The demonstration of elevated levels of vasoactive intestinal polypeptide in both tumor and plasma and the ultrastructural description of endocrine granules may help to explain the pathophysiology in this case.
本文报告一例胰腺非β胰岛细胞瘤，该肿瘤导致了WDHA（水样腹泻、低钾血症和无胃酸）综合征。经轴位视图显示胰腺体尾部增大；同时还注意到多个大小肠充满液体的肠袢。该肿瘤的血管造影与其他非β胰岛细胞病变相似，表现为一个大的高血管肿块，供血血管增粗，并有持续、浓密的毛细血管染色。肿瘤和血浆中血管活性肠肽水平升高的证实以及内分泌颗粒的超微结构描述可能有助于解释该病例的病理生理学。
