Stein Sherman C, Guo Wensheng
Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19106, USA.
J Neurosurg Pediatr. 2008 Jan;1(1):40-7. doi: 10.3171/PED-08/01/040.
The goal of this study was to determine whether failure rates of hydrocephalus shunts have fallen over the years as a result of experience or technical improvements.
A structured search was performed of the English language literature for case series reporting failure rates after shunt insertion. A metaanalytic model was constructed to pool data from multiple studies and to analyze failure rates statistically for temporal trends. Separate models were used for children (< 17 years old) and adults.
In children, the shunt failure rate was 31.3% for the 1st year and 4.5% per year thereafter. There were no significant changes in either rate over time. Although 1st-year failure rates in adults have fallen slightly over time, late failure rates have risen.
Progress in preventing shunt failures has not been made over the last several decades. Any improvements made in shunt materials or insertion techniques have been overshadowed by biological and other factors.
本研究的目的是确定多年来脑积水分流术的失败率是否因经验积累或技术改进而有所下降。
对英文文献进行结构化检索,查找报告分流术后失败率的病例系列。构建荟萃分析模型以汇总来自多项研究的数据,并对失败率进行时间趋势的统计分析。分别为儿童(<17岁)和成人使用单独的模型。
在儿童中,第一年的分流失败率为31.3%,此后每年为4.5%。这两个比率随时间均无显著变化。尽管成人第一年的失败率随时间略有下降,但后期失败率有所上升。
在过去几十年中,预防分流失败方面没有取得进展。分流材料或插入技术的任何改进都被生物学和其他因素所掩盖。