Singh Sunit K
Centre for Cellular and Molecular Biology, Section of Infectious Diseases & Immunobiology, Room No: S107, South Wing (Ground Floor), Uppal Road, Hyderabad-500007, AP, India.
Expert Opin Biol Ther. 2008 Apr;8(4):449-61. doi: 10.1517/14712598.8.4.449.
HIV-1 infection is the major cause of AIDS. RNA interference (RNAi) has great potential to work as a powerful tool against HIV infection. Therefore, the possibilities of use of siRNA (small-interfering RNA) as a tool to deal with HIV infection are discussed in this article.
Highly active anti retroviral therapy (HAART) has been successful in reducing the rate of progression to AIDS, but HIV utilizes various tricks to escape from the inhibitory effect of HAART. Therefore, new tools are required to delay progression of infection or block the replication cycle of HIV.
This article has been written on the basis of informations available in the form of published literature in various journals.
RNAi is a very promising strategy that in principle will provide many new targets against HIV infection. The mechanism of sequence complementarity utilized by siRNAs against their targets provides a new approach to fight against HIV infection. However, this technology still needs many fine refinements before its potential for HIV treatment strategies can be utilized. This review discusses the possibilities of using siRNA as a therapeutic tool for HIV treatment.
HIV-1感染是艾滋病的主要病因。RNA干扰（RNAi）作为对抗HIV感染的有力工具具有巨大潜力。因此，本文讨论了使用小干扰RNA（siRNA）作为应对HIV感染工具的可能性。
高效抗逆转录病毒疗法（HAART）已成功降低了发展为艾滋病的速率，但HIV利用各种手段逃避HAART的抑制作用。因此，需要新的工具来延缓感染进程或阻断HIV的复制周期。
本文是根据各种期刊上发表的文献中提供的信息撰写的。
RNAi是一种非常有前景的策略，原则上它将提供许多针对HIV感染的新靶点。siRNA针对其靶点利用的序列互补机制为对抗HIV感染提供了一种新方法。然而，在其用于HIV治疗策略的潜力得以发挥之前，这项技术仍需要许多精细的改进。本综述讨论了使用siRNA作为HIV治疗的治疗工具的可能性。
