Posselt A M, Naji A, Roark J H, Markmann J F, Barker C F
Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia 19104.
Ann Surg. 1991 Oct;214(4):363-71; discussion 371-3. doi: 10.1097/00000658-199110000-00001.
Recently it was demonstrated that pancreatic islet allografts transplanted to the thymus of rats made diabetic chemically are not rejected and induce specific unresponsiveness to subsequent extrathymic transplants. The authors report that the thymus can also serve as an effective islet transplantation site in spontaneously diabetic BB rats, in which autoimmunity and rejection can destroy islets. Intrathymic Lewis islet grafts consistently reversed hyperglycemia for more than 120 days in these rats, and in three of four recipients the grafts promoted subsequent survival of intraportal islets. In contrast intraportal islet allografts in naive BB hosts all failed rapidly. The authors also show that the immunologically privileged status of the thymus cannot prevent rejection of islet allografts in Wistar Furth (WF) rats sensitized with donor strain skin and that suppressor cells are not likely to contribute to the unresponsive state because adoptive transfer of spleen cells from WF rats bearing established intrathymic Lewis islets fails to prolong islet allograft survival in secondary hosts.
最近有研究表明，移植到经化学方法诱导糖尿病的大鼠胸腺中的胰岛同种异体移植物不会被排斥，并且会诱导对随后的胸腺外移植产生特异性无反应性。作者报告称，在自发性糖尿病BB大鼠中，胸腺也可作为有效的胰岛移植部位，在这类大鼠中，自身免疫和排斥反应会破坏胰岛。在这些大鼠中，胸腺内的刘易斯胰岛移植物持续使高血糖症逆转超过120天，并且在四分之三的受体中，这些移植物促进了随后门静脉内胰岛的存活。相比之下，未接触过抗原的BB宿主中的门静脉内胰岛同种异体移植物均迅速失败。作者还表明，胸腺的免疫特惠状态无法阻止在用供体品系皮肤致敏的Wistar Furth（WF）大鼠中胰岛同种异体移植物被排斥，并且抑制细胞不太可能导致无反应状态，因为将携带已建立的胸腺内刘易斯胰岛的WF大鼠的脾细胞进行过继转移，无法延长二次宿主中胰岛同种异体移植物的存活时间。
