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[机体适应高原时钙调节腺体的结构重组]

[The structural reorganization of the calcium-regulating glands in body adaptation to high altitude].

作者信息

Khmel'nitskiĭ O K, Tararak T Ia

出版信息

Arkh Patol. 1991;53(6):33-7.

PMID:1835367
Abstract

The parathyroid cells and thyroid C-cells were studied morphologically, morphometrically and electron microscopically at the altitude of 3200 m. The increase of functional activity of both parathyroid cells and thyroid cells was observed starting from the 7th day of being at the high altitude. This was manifested in the increase of C-cell number, their size and ultrastructurally in the cell organelles hyperplasia and hypertrophy. As distinct from the normal altitude, high activity of the parathyroid cells was not compensated by an increased function of C-cells, this dysfunction resulting in a high blood level of calcium which may serve as a criterion of this hormonal system adaptivity and as an index of a new level of calcium homeostasis.

摘要

在海拔3200米处,对甲状旁腺细胞和甲状腺C细胞进行了形态学、形态计量学和电子显微镜研究。从到达高海拔地区的第7天开始,观察到甲状旁腺细胞和甲状腺细胞的功能活性均增加。这表现为C细胞数量增加、大小增大,在超微结构上表现为细胞器增生和肥大。与正常海拔不同,甲状旁腺细胞的高活性并未因C细胞功能增强而得到补偿,这种功能障碍导致血液中钙水平升高,这可作为该激素系统适应性的标准以及钙稳态新水平的指标。

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