Torkamanzehi Adam, Boksa Patricia, Joober Ridha
University of Sistan and Baluchestan, Zahedan PO Box 98155-987, Iran.
J Genet Genomics. 2008 Mar;35(3):139-51. doi: 10.1016/S1673-8527(08)60020-X.
Prepulse inhibition (PPI) of the startle response is a psychophysiological measure of sensorimotor gating believed to be cross-modal between different sensory systems. We analyzed the tactile startle response (TSR) and PPI of TSR (tPPI), using light as a prepulse stimulus, in the mouse strains A/J and C57BL/6J and 36 recombinant congenic strains derived from them. Parental strains were significantly different for TSR, but were comparable for tPPI. Among the congenic strains, variation for TSR was significant in both genetic backgrounds, but that of tPPI was significant only for the C57BL/6J background. Provisional mapping for loci modulating TSR and tPPI was carried out. Using mapping data from our previous study on acoustic startle responses (ASR) and PPI of ASR (aPPI), no common markers for aPPI and tPPI were identified. However, some markers were significantly associated with both ASR and TSR, at least in one genetic background. These results indicate cross-modal genetic regulation for the startle response but not for PPI, in these mouse strains.
惊吓反应的前脉冲抑制（PPI）是一种感觉运动门控的心理生理测量方法，被认为在不同感觉系统之间是跨模态的。我们使用光作为前脉冲刺激，分析了A/J和C57BL/6J小鼠品系以及由它们衍生的36个重组近交系的触觉惊吓反应（TSR）和TSR的PPI（tPPI）。亲本品系在TSR方面有显著差异，但在tPPI方面相当。在近交系中，TSR的变异在两种遗传背景下都很显著，但tPPI的变异仅在C57BL/6J背景下显著。对调节TSR和tPPI的基因座进行了初步定位。利用我们之前关于听觉惊吓反应（ASR）和ASR的PPI（aPPI）的研究中的定位数据，未发现aPPI和tPPI的共同标记。然而，至少在一种遗传背景下，一些标记与ASR和TSR都显著相关。这些结果表明，在这些小鼠品系中，惊吓反应存在跨模态遗传调控，但PPI不存在。
