阿尔茨海默病和多发梗死性痴呆患者血清硫酸脱氢表雄酮水平

Serum dehydroepiandrosterone sulfate in Alzheimer's disease and in multi-infarct dementia.

作者信息

Näsman B, Olsson T, Bäckström T, Eriksson S, Grankvist K, Viitanen M, Bucht G

机构信息

Department of Geriatric Medicine, Umeå University Hospital, Sweden.

出版信息

Biol Psychiatry. 1991 Oct 1;30(7):684-90. doi: 10.1016/0006-3223(91)90013-c.

DOI:10.1016/0006-3223(91)90013-c

PMID:1835658

Abstract

Circulating levels of dehydroepiandrosterone sulfate (DHEAS) and cortisol were studied in 86 patients with dementia; 45 with Alzheimer's disease and 41 with multi-infarct dementia. Compared to an elderly control group, after adjustment for age and sex, patients with Alzheimer's disease were found to have lower serum levels of DHEAS. We found a covariation between serum albumin and DHEAS levels, which may be of importance regarding peripheral hormone concentration in patients with dementia. These findings may provide evidence for a role of DHEAS in amnestic disorder in humans, either reflecting or contributing to the course of dementing diseases.

摘要

对86例痴呆患者的硫酸脱氢表雄酮（DHEAS）和皮质醇循环水平进行了研究，其中45例为阿尔茨海默病患者，41例为多发梗死性痴呆患者。与老年对照组相比，在调整年龄和性别后，发现阿尔茨海默病患者的血清DHEAS水平较低。我们发现血清白蛋白和DHEAS水平之间存在协变关系，这可能对痴呆患者外周激素浓度具有重要意义。这些发现可能为DHEAS在人类遗忘症中的作用提供证据，其可能反映或影响痴呆疾病的进程。