术前正常结膜细菌的体外抗生素药敏性。
In vitro antibiotic susceptibility of preoperative normal conjunctival bacteria.
机构信息
Department of Ophthalmology, School of Medicine, Stanford University, Stanford, CA 94305, USA. cta@ stanford.edu
出版信息
Eye (Lond). 2009 Mar;23(3):559-60. doi: 10.1038/eye.2008.65. Epub 2008 Mar 21.
PURPOSE
To determine the antibiotic susceptibility of preoperative conjunctival bacterial flora.
METHODS
Antibiotic susceptibility of conjunctival bacterial strains isolated from 142 patients undergoing intraocular surgery was determined using the Kirby-Bauer disc diffusion technique. chi(2) statistical analysis was performed.
RESULTS
Among the 116 bacteria isolated, 95 (82%) were coagulase-negative staphylococci (CNS). Most (>75%) of them were susceptible to vancomycin, minocycline, aminoglycosides, gatifloxacin, levofloxacin, and moxifloxacin. Approximately one-half of CNS was resistant to erythromycin and azithromycin. Over 90% of streptococci were susceptible to levofloxacin, moxifloxacin, and gatifloxacin.
RESULTS
Fluoroquinolones, specifically gatifloxacin, levofloxacin, and moxifloxacin continue to provide broad-spectrum coverage against common conjunctival bacterial flora.
目的
确定术前结膜菌群的抗生素敏感性。
方法
采用 Kirby-Bauer 纸片扩散法测定 142 例眼内手术患者结膜分离菌株的抗生素敏感性。进行卡方统计分析。
结果
在分离出的 116 株细菌中，95 株（82%）为凝固酶阴性葡萄球菌（CNS）。它们大多（>75%）对万古霉素、米诺环素、氨基糖苷类、加替沙星、左氧氟沙星和莫西沙星敏感。约一半的 CNS 对红霉素和阿奇霉素耐药。超过 90%的链球菌对左氧氟沙星、莫西沙星和加替沙星敏感。
结果
氟喹诺酮类药物，特别是加替沙星、左氧氟沙星和莫西沙星，继续对常见的结膜菌群提供广谱覆盖。
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