对一名患有直肠癌的孕妇使用奥沙利铂。
Administration of oxaliplatin to a pregnant woman with rectal cancer.
作者信息
Gensheimer Michael, Jones Catherine A, Graves Cornelia R, Merchant Nipun B, Lockhart A Craig
机构信息
Vanderbilt University School of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
出版信息
Cancer Chemother Pharmacol. 2009 Jan;63(2):371-3. doi: 10.1007/s00280-008-0731-9. Epub 2008 Mar 21.
PURPOSE
The platinum agent oxaliplatin could be useful in treatment of cancer in pregnant women, but it is fetotoxic in rats and its effect on the human fetus is unknown.
METHODS
Oxaliplatin was administered to a 25-year-old pregnant woman with metastatic rectal cancer from 20 to 30 weeks gestational age as part of the mFOLFOX-6 regimen.
RESULTS
The patient gave birth to a healthy girl at 33 weeks gestational age. At follow-up, the 3-year-old child had achieved all appropriate growth and developmental milestones.
DISCUSSION
Oxaliplatin is a component of several modern chemotherapy regimens. This report demonstrates the administration of oxaliplatin in the second and third trimesters of pregnancy without apparent fetal harm.
目的
铂类药物奥沙利铂可能对治疗孕妇癌症有用，但它对大鼠具有胚胎毒性，其对人类胎儿的影响尚不清楚。
方法
作为mFOLFOX-6方案的一部分，在孕20至30周时给一名患有转移性直肠癌的25岁孕妇使用奥沙利铂。
结果
该患者在孕33周时产下一名健康女婴。随访时，这个3岁的孩子达到了所有适当的生长和发育里程碑。
讨论
奥沙利铂是几种现代化疗方案的组成部分。本报告证明了在妊娠中期和晚期使用奥沙利铂并未对胎儿造成明显伤害。
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