Mohamed Ismail S, Cheyne Douglas, Gaetz William C, Otsubo Hiroshi, Logan William J, Carter Snead O, Pang Elizabeth W
Division of Neurology, Alberta Children's Hospital, Calgary, Alberta, Canada.
Int J Psychophysiol. 2008 May;68(2):141-8. doi: 10.1016/j.ijpsycho.2007.11.005. Epub 2008 Feb 8.
We studied the task-induced spatiotemporal evolution and characteristics of cortical neural oscillations in children during an auditory word recognition task.
We presented abstract nouns binaurally and recorded the MEG response in eight healthy right-handed children (6-12 years). We calculated the event-related changes in cortical oscillations using a beamformer spatial filter analysis technique (SAM), then transformed each subject's statistical maps into standard space and used these to make group statistical inferences.
Across subjects, the cortical response to words could be divided into at least two phases: an initial event-related synchronization in both the right temporal (100-300 ms, 15-25 Hz; 200-400 ms, 5-15 Hz) and left frontal regions (200-400 ms; 15-25 Hz); followed by a strong left-lateralized event-related desynchronization in the left temporal region (500-700 ms; 5-15 Hz).
We found bilateral event-related synchronization followed by later left lateralized event-related desynchronization in language-related cortical areas. These data demonstrate the spatiotemporal time course of neural activation during an auditory word recognition task in a group of children. As well, this demonstrates the utility of SAM analyses to detect subtle sequential task-related neural activations.
我们研究了儿童在听觉单词识别任务期间任务诱发的皮层神经振荡的时空演变及特征。
我们向八名健康的右利手儿童（6 - 12岁）双耳呈现抽象名词，并记录其脑磁图反应。我们使用波束形成器空间滤波分析技术（SAM）计算皮层振荡的事件相关变化，然后将每个受试者的统计图谱转换到标准空间，并以此进行组间统计推断。
在所有受试者中，对单词的皮层反应可分为至少两个阶段：右颞叶（100 - 300毫秒，15 - 25赫兹；200 - 400毫秒，5 - 15赫兹）和左额叶区域（200 - 400毫秒；15 - 25赫兹）最初的事件相关同步；随后是左颞叶区域强烈的左侧化事件相关去同步（500 - 700毫秒；5 - 15赫兹）。
我们发现在与语言相关的皮层区域中，先是双侧事件相关同步，随后是后期左侧化事件相关去同步。这些数据展示了一组儿童在听觉单词识别任务期间神经激活的时空进程。同时，这也证明了SAM分析在检测与任务相关的细微连续神经激活方面的效用。
