Liu Zhong-lin, Wang Li-min, Tao En-xiang
Department of Neurology, Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China. zhonglinliu126.com
Nan Fang Yi Ke Da Xue Xue Bao. 2008 Mar;28(3):447-8.
To investigate the clinical heterogeneity of movement disorder in Parkinson's disease (PD).
Ninety-eight PD patients (68 males and 30 females) were divided into tremor-dominant PD (n=23), mixed subtype PD (n=29) and postural instability and gait disorder (PIGD)-dominant PD (n=46) groups, and the clinical heterogeneity of the movement function of the patients was compared.
The initial symptom of tremor-predominant PD was tremor, but patients with PIGD-dominant PD had rigidity and gait disorder as the initial symptoms, commonly compromising the left limb. The amended Hoehn-Yahr stage of tremor-dominant PD was significantly lower than that of the PIGD-dominant PD, while the score of Mini-Mental State Examination (MMSE) was significantly higher in the former. No statistical differences were found in the gender, course of disease and family history between the patients with different subtypes of PD.
There are significant differences in the initial and typical symptoms between tremor-dominant PD and PIGD-dominant PD.
探讨帕金森病（PD）运动障碍的临床异质性。
将98例PD患者（68例男性和30例女性）分为震颤为主型PD组（n = 23）、混合型PD组（n = 29）和姿势不稳和步态障碍（PIGD）为主型PD组（n = 46），比较患者运动功能的临床异质性。
震颤为主型PD患者初始症状为震颤，而PIGD为主型PD患者初始症状为强直和步态障碍，常累及左侧肢体。震颤为主型PD的改良Hoehn-Yahr分期显著低于PIGD为主型PD，而前者的简易精神状态检查表（MMSE）评分显著更高。不同亚型PD患者之间在性别、病程和家族史方面未发现统计学差异。
震颤为主型PD和PIGD为主型PD在初始症状和典型症状方面存在显著差异。
