与多种抑制剂（别嘌醇、非布司他和FYX-051）结合的哺乳动物黄嘌呤氧化还原酶的晶体结构。
Crystal structures of mammalian xanthine oxidoreductase bound with various inhibitors: allopurinol, febuxostat, and FYX-051.
作者信息
Okamoto Ken, Nishino Takeshi
机构信息
Department of Medical and Biological Chemistry, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
出版信息
J Nippon Med Sch. 2008 Feb;75(1):2-3. doi: 10.1272/jnms.75.2.
PMID:18360072
Abstract
Xanthine oxidoreductase (XOR) catalyzes the reaction of hypoxanthine to xanthine and of xanthine to uric acid. Inhibitors of XOR can thus decrease the concentration of uric acid in serum. Crystal structures of XOR bound with various inhibitors reveal that inhibitors can be categorized into three types, i.e. mechanism-based, structure-based, and hybrid types.
摘要
黄嘌呤氧化还原酶（XOR）催化次黄嘌呤向黄嘌呤以及黄嘌呤向尿酸的反应。因此，XOR抑制剂可降低血清中尿酸的浓度。XOR与各种抑制剂结合的晶体结构表明，抑制剂可分为三种类型，即基于机制型、基于结构型和混合型。
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