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实际和预期的全科医生处方他汀类药物、ACE 抑制剂和β受体阻滞剂的比率之间的差异关联:英格兰的一项横断面研究。

Differential associations between actual and expected GP practice prescribing rates for statins, ACE inhibitors, and beta-blockers: a cross-sectional study in England.

出版信息

Ther Clin Risk Manag. 2005 Mar;1(1):61-8. doi: 10.2147/tcrm.1.1.61.53599.

DOI:10.2147/tcrm.1.1.61.53599
PMID:18360545
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1661602/
Abstract

AIM

To explore the relationship between actual and expected general medical practitioner (GP) practice prescribing rates for statins, angiotensin converting enzyme (ACE) inhibitors, and beta-blockers.

BACKGROUND

There is a growing body of literature highlighting inequities in GP practice prescribing rates for many drug therapies. The equity of prescribing is of central importance in the area of therapeutics since it explores the interface between those patients who should and those who actually do receive a drug therapy.

SETTING

Four primary care trusts (PCTs 1-4) in the North West of England, including 132 GP practices.

METHODS

Actual and expected prescribing rates for statins, beta-blockers, and ACE inhibitors were specifically developed for each GP practice.

RESULTS

There were no statistically significant correlations between actual and expected prescribing rates in PCT2 and PCT3, although in PCT1 there were statistically significant correlations for statins (0.286, p < 0.05) and ACE inhibitors (0.381, p < 0.01). In PCT4, correlations were moderate to high for beta-blockers (0.693, p < 0.01), and moderate for statins (0.541, p < 0.05) and ACE inhibitors (0.585, p < 0.01). Scatterplots highlighted large variations between individual GP practices (both within and between PCTs) in terms of the relationship between actual and expected prescribing rates.

CONCLUSION

This paper highlights variability between PCTs and GP practices in terms of the relationship between actual and expected prescribing rates. The findings from this paper may further advance the suggestion of inequities in prescribing rates for coronary heart disease (CHD) drugs, and studies such as this may be repeated in different therapeutic areas, healthcare settings, and countries.

摘要

目的

探讨实际和预期的全科医生(GP)他汀类药物、血管紧张素转换酶(ACE)抑制剂和β受体阻滞剂处方率之间的关系。

背景

越来越多的文献强调了许多药物治疗的 GP 实践处方率存在不平等现象。处方的公平性在治疗领域中至关重要,因为它探讨了那些应该接受药物治疗的患者和实际接受药物治疗的患者之间的界面。

设置

英格兰西北部的四个初级保健信托(PCT1-4),包括 132 个全科医生诊所。

方法

为每个全科医生诊所专门制定了他汀类药物、β受体阻滞剂和 ACE 抑制剂的实际和预期处方率。

结果

在 PCT2 和 PCT3 中,实际和预期的处方率之间没有统计学上的显著相关性,尽管在 PCT1 中,他汀类药物(0.286,p < 0.05)和 ACE 抑制剂(0.381,p < 0.01)有统计学上的显著相关性。在 PCT4 中,β受体阻滞剂的相关性为中度至高度(0.693,p < 0.01),他汀类药物(0.541,p < 0.05)和 ACE 抑制剂(0.585,p < 0.01)的相关性为中度。散点图突出了个体全科医生诊所(PCT 内和之间)之间在实际和预期处方率之间的关系方面存在很大差异。

结论

本文强调了不同 PCT 和全科医生诊所之间在实际和预期处方率之间的关系方面存在差异。本文的研究结果可能进一步证明了冠心病药物处方率的不平等现象,并可能在不同的治疗领域、医疗保健环境和国家重复进行此类研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803e/1661602/e87c0fc892ba/tcrm0101-061-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803e/1661602/9c4b8299c229/tcrm0101-061-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803e/1661602/4b553f4e7cc2/tcrm0101-061-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803e/1661602/e87c0fc892ba/tcrm0101-061-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803e/1661602/9c4b8299c229/tcrm0101-061-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803e/1661602/4b553f4e7cc2/tcrm0101-061-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/803e/1661602/e87c0fc892ba/tcrm0101-061-f3.jpg

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引用本文的文献

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2
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本文引用的文献

1
Average daily quantities: a tool for measuring prescribing volume in England.日均用量:衡量英格兰开药量的工具。
Pharmacoepidemiol Drug Saf. 2000 Jan;9(1):55-8. doi: 10.1002/(SICI)1099-1557(200001/02)9:1<55::AID-PDS467>3.0.CO;2-H.
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Multivariate regression analysis of associations between general practitioner prescribing rates for coronary heart disease drugs and healthcare needs indicators.全科医生开具冠心病药物的处方率与医疗保健需求指标之间关联的多变量回归分析。
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Are GP practice prescribing rates for coronary heart disease drugs equitable? A cross sectional analysis in four primary care trusts in England.
全科医生对冠心病药物的处方率是否公平?对英格兰四个初级医疗信托基金的横断面分析。
J Epidemiol Community Health. 2004 Feb;58(2):89-96. doi: 10.1136/jech.58.2.89.
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Developing prevalence-based prescribing units for analysing variations in general practitioner prescribing: a case study using statins.开发基于患病率的处方单位以分析全科医生处方差异:使用他汀类药物的案例研究
J Clin Pharm Ther. 2003 Feb;28(1):23-9. doi: 10.1046/j.1365-2710.2003.00451.x.
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Prescribing of lipid lowering drugs to South Asian patients: ecological study.给南亚患者开具降脂药物:生态学研究。
BMJ. 2002 Jul 6;325(7354):25-6. doi: 10.1136/bmj.325.7354.25.
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Equity of access to health care services: theory and evidence from the UK.医疗保健服务的可及性公平性:来自英国的理论与证据
Soc Sci Med. 2001 Nov;53(9):1149-62. doi: 10.1016/s0277-9536(00)00415-9.
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Prescribing information systems; making sense of primary care data.处方信息系统;解读基层医疗数据。
J Clin Pharm Ther. 2001 Aug;26(4):235-9. doi: 10.1046/j.1365-2710.2001.00352.x.
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Prescribing at the Primary Care Group level: census data and prescribing indicators.基层医疗集团层面的处方开具:人口普查数据与处方指标
J Clin Pharm Ther. 2001 Apr;26(2):93-101. doi: 10.1046/j.1365-2710.2001.00320.x.
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Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials. Blood Pressure Lowering Treatment Trialists' Collaboration.血管紧张素转换酶抑制剂、钙拮抗剂及其他降压药物的作用:前瞻性设计的随机试验综述结果。降压治疗试验协作组
Lancet. 2000 Dec 9;356(9246):1955-64. doi: 10.1016/s0140-6736(00)03307-9.
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