Ther Clin Risk Manag. 2005 Jun;1(2):151-6. doi: 10.2147/tcrm.1.2.151.62914.
Prescribing for older people is challenging because of the paucity of clinical trial evidence of therapeutic benefit in this population and the presence of evidence that older people are at increased risk of adverse drug reactions. The outcomes of pharmacotherapies in older people depend on age-related changes in both pharmacokinetics and pharmacodynamics. Of the pharmacokinetic changes, those in hepatic metabolism are the most significant. Recent advances in biogerontology have improved our understanding of changes that occur in hepatic pharmacokinetics in older people. Knowledge of age-related changes in hepatic metabolism can guide prescribing and help reduce the risk-benefit ratio of using medications in older people.
为老年人开处方具有挑战性，因为在这一人群中，治疗益处的临床试验证据很少，而且有证据表明老年人面临更高的药物不良反应风险。老年人的药物治疗结果取决于药代动力学和药效学的年龄相关性变化。在药代动力学变化中，肝代谢的变化最为显著。生物老年学的最新进展提高了我们对老年人肝药代动力学变化的认识。了解肝代谢的年龄相关性变化可以指导处方，并有助于降低老年人使用药物的风险效益比。
