Li Nai-Shi, Li Wen-Hui, Wang Heng
Department of Endocrinology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2008 Feb;30(1):109-11.
To investigate the feasibility of perioperative glycemic control with insulin glargine in type 2 diabetic patients.
We retrospectively analyzed the clinical data of 16 type 2 diabetic inpatients treated with insulin glargine (research group) and 16 type 2 diabetic inpatients treated with the traditional intensified insulin therapy (control group) for perioperative glycemic control.
The fasting blood glucose values of the diabetic patients in the research group on the day of surgery and the first 3 postoperative days were (7.5 +/- 1.8), (8.2 +/- 1.8), (7.6 +/- 1.6), and (7.2 +/- 1.1) mmol/L, respectively, and were (9.0 +/- 2.8), (10.4 +/- 2.4), (8.8 +/- 2.7), (9.0 +/- 2.0) mmol/L in the control group, respectively. The fasting blood glucose values in the research group were significantly lower than the control group on the first and third postoperative day (P = 0.02 and 0.01, respectively). No hypoglycemic events were observed and all wounds were healed well in both groups.
With satisfied fasting blood glucose level and fewer episode of hypoglycemia, perioperative glycemic control by insulin glargine in type 2 diabetic patients is safe, effective, and convenient.
探讨甘精胰岛素用于2型糖尿病患者围手术期血糖控制的可行性。
回顾性分析16例接受甘精胰岛素治疗的2型糖尿病住院患者（研究组）和16例接受传统强化胰岛素治疗的2型糖尿病住院患者（对照组）围手术期血糖控制的临床资料。
研究组糖尿病患者手术当日及术后前3天的空腹血糖值分别为（7.5±1.8）、（8.2±1.8）、（7.6±1.6）和（7.2±1.1）mmol/L，对照组分别为（9.0±2.8）、（10.4±2.4）、（8.8±2.7）、（9.0±2.0）mmol/L。研究组术后第1天和第3天的空腹血糖值显著低于对照组（P分别为0.02和0.01）。两组均未观察到低血糖事件，所有伤口均愈合良好。
甘精胰岛素用于2型糖尿病患者围手术期血糖控制，空腹血糖水平满意，低血糖发作较少，安全、有效且方便。
