Verma S C, McNeill J H
Arch Int Pharmacodyn Ther. 1976 May;221(1):4-8.
Injection of 1.0 mg theophylline and 1.6 mg imidazole into guinea-pig hearts perfused by the Langendorff technique increased cardiac contractile force by 20.0 +/- 1.0% and 23.3 +/- 1.2% over control and activated phosphorylase without producing significant changes in cyclic AMP levels. When guinea-pig hearts were perfused with theophylline (10(-3) M) or imidazole (20 mM), injection of either imidazole or theophylline did not further increase cardiac contractility or phosphorylase a levels. In all cases there was no change in cycylic AMP levels. Data in the literature indicate that calcium plays a role in the cardiac biochemical and mechanical effects of theophylline and imidazole. Both drugs may thus produce their cardiac effects by a calcium rather than a cyclic AMP mediated mechanism.
向采用Langendorff技术灌注的豚鼠心脏注射1.0毫克茶碱和1.6毫克咪唑，与对照组相比，心脏收缩力分别增加了20.0±1.0%和23.3±1.2%，并激活了磷酸化酶，而环磷酸腺苷水平没有显著变化。当用茶碱（10⁻³ M）或咪唑（20 mM）灌注豚鼠心脏时，注射咪唑或茶碱均不会进一步增加心脏收缩力或磷酸化酶a水平。在所有情况下，环磷酸腺苷水平均无变化。文献数据表明，钙在茶碱和咪唑对心脏的生化及机械作用中发挥作用。因此，这两种药物可能通过钙介导而非环磷酸腺苷介导的机制产生心脏效应。
