McNeill J H
Res Commun Chem Pathol Pharmacol. 1978 Jun;20(3):597-600.
Dobutamine produced a dose-dependent increase in cardiac cyclic AMP, % phosphorylase a and contractile force in the isolated perfused rat heart. Cyclic AMP increased prior to the increase in % phosphorylase a and prior to or concomitant with the increase in force. Similar results were obtained with isoproterenol except that the effects of isoproterenol occurred slightly earlier. The efficacy of both amines was approximately the same but dobutamine was was about 1/45 as potent as isoproterenol.
多巴酚丁胺可使离体灌注大鼠心脏的心肌环磷酸腺苷（cAMP）、磷酸化酶a的百分比及收缩力呈剂量依赖性增加。环磷酸腺苷在磷酸化酶a百分比增加之前以及在收缩力增加之前或同时增加。异丙肾上腺素也得到了类似的结果，只是异丙肾上腺素的作用出现得稍早一些。两种胺类药物的疗效大致相同，但多巴酚丁胺的效力约为异丙肾上腺素的1/45。
