Pentimone F, del Corso Daniela Moruzzo L, Romanelli A M
Istituto di Clinica Medica II, Università degli Studi di Pisa.
Clin Ter. 1991;138(5-6):199-205.
The authors describe serum sodium levels in elderly patients at hospitalization and evaluate the role attributable to drugs, diseases, nutrition and fluid balance. Among 167 patients (average age 75.29 +/- 7.14), 132 (79.04%) had normal sodium balance, 34 (20.36%) were hyponatremic and only 1 (0.60%) was hypernatremic. Patients who had serum sodium levels above 129 mEq/l were asymptomatic. In five cases hyponatremia was acute and severe (less than or equal to 127 mEq/l). Seven patients who had serum sodium levels less than 127 mEq/l presented psychiatric and neurological manifestations, which subsided completely after prompt correction of the electrolyte disorder. The authors suggest that the pathogenesis of hyponatremia in pathological states in the elderly is complex, although iatrogenic causes play a fundamental role.
作者描述了老年患者住院时的血清钠水平,并评估了药物、疾病、营养和液体平衡所起的作用。在167例患者(平均年龄75.29±7.14岁)中,132例(79.04%)钠平衡正常,34例(20.36%)为低钠血症,仅有1例(0.60%)为高钠血症。血清钠水平高于129 mEq/l的患者无症状。5例低钠血症为急性且严重(≤127 mEq/l)。7例血清钠水平低于127 mEq/l的患者出现精神和神经症状,在迅速纠正电解质紊乱后症状完全消失。作者认为,尽管医源性原因起主要作用,但老年人病理状态下低钠血症的发病机制很复杂。