乳腺癌患者外科护理中的临床试验优先级。
Clinical trial priorities among surgeons caring for breast cancer patients.
作者信息
Schroen Anneke T, Brenin David R
机构信息
Department of Surgery, University of Virginia, PO Box 800709, Charlottesville, VA 22908-0709, USA.
出版信息
Am J Surg. 2008 Apr;195(4):474-80. doi: 10.1016/j.amjsurg.2007.03.014.
BACKGROUND
Designing and prioritizing successful clinical trials benefits from increased community physician input. We surveyed practicing surgeons about current controversies in breast cancer surgery, reported practices of discussing trial participation, and perceived obstacles to trial participation.
METHODS
A 44-question survey was mailed in 2005-2006 to 2,187 randomly selected American College of Surgeons members actively seeing breast cancer patients. Responses were analyzed by surgeon sex, practice type, oncology training, professional society membership, and breast cancer patient volume.
RESULTS
A total of 923 responses were received, with 460 eligible responses remaining for analysis. Most surgeons infrequently or never discuss trial participation with breast cancer patients. Inadequate infrastructure presents the greatest physician obstacle to trial participation. Identifying proven indications for completion axillary dissection after positive sentinel node biopsy marks the highest-ranked research priority for surgeons providing breast care.
CONCLUSIONS
Understanding topics of interest among practicing surgeons and addressing common obstacles to trial participation may result in improved breast cancer patient accrual through surgeons.
背景
增加社区医生的参与有助于设计成功的临床试验并确定其优先顺序。我们就乳腺癌手术当前存在的争议、报告的讨论试验参与情况的做法以及试验参与的感知障碍，对执业外科医生进行了调查。
方法
2005年至2006年，向随机抽取的2187名积极诊治乳腺癌患者的美国外科医师学会成员邮寄了一份包含44个问题的调查问卷。根据外科医生的性别、执业类型、肿瘤学培训、专业学会会员资格以及乳腺癌患者数量对回复进行分析。
结果
共收到923份回复，其中460份合格回复可供分析。大多数外科医生很少或从不与乳腺癌患者讨论试验参与情况。基础设施不足是医生参与试验的最大障碍。确定前哨淋巴结活检阳性后完成腋窝清扫的已证实指征是提供乳腺护理的外科医生排名最高的研究重点。
结论
了解执业外科医生感兴趣的话题并解决试验参与的常见障碍，可能会通过外科医生提高乳腺癌患者的入组率。
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