Hulstaert C E, Kalicharan D, Poelstra K, Bakker W W, Hardonk M J
Department of Histology and Cell Biology, University of Groningen, The Netherlands.
Histochemistry. 1991;96(5):441-7. doi: 10.1007/BF00316002.
The extracellular presence of adenosine polyphosphatase was investigated in a number of rat tissues. The enzyme was demonstrated in basement membranes of epithelial cells of duodenum, urinary bladder, tongue, choroid plexus, submandibular salivary gland, lung and kidney, as well as in basement membranes of capillaries in these tissues. Furthermore adenosine polyphosphatase was demonstrated on collagen fibrils and in the cytoplasm of fibroblasts of all investigated tissues. It appears that the presence of adenosine polyphosphatase in basement membranes is a widespread phenomenon. Since extracellular ADP and ATP are known to promote respectively platelet aggregation and inflammation, the presence of extracellular ADP and ATP-hydrolyzing activity might contribute to inhibit these processes.
研究了多种大鼠组织中胞外腺苷多磷酸酶的存在情况。在十二指肠、膀胱、舌、脉络丛、下颌下唾液腺、肺和肾的上皮细胞基底膜中，以及这些组织中毛细血管的基底膜中均证实有该酶存在。此外，在所有研究组织的胶原纤维和成纤维细胞的细胞质中也证实有腺苷多磷酸酶存在。看来基底膜中腺苷多磷酸酶的存在是一种普遍现象。由于已知胞外二磷酸腺苷（ADP）和三磷酸腺苷（ATP）分别可促进血小板聚集和炎症反应，胞外ADP和ATP水解活性的存在可能有助于抑制这些过程。
