Ono N, Koyama T, Suehiro A, Oku K, Fujikake K, Kakishita E
Second Department of Internal Medicine, Hyogo College of Medicine, Japan.
Stroke. 1991 Nov;22(11):1369-73. doi: 10.1161/01.str.22.11.1369.
We investigated plasma levels of D-dimer products of crosslinked fibrin degradation products, thrombin-antithrombin III complex, and plasmin-alpha 2-antiplasmin complex for detecting coagulation system activation in ischemic stroke patients to determine the possible effect of age on these marker levels.
We measured plasma levels of these three markers in 54 acute ischemic stroke patients within 5 days of stroke onset, in 44 chronic ischemic stroke patients over 3 months from onset, and in 50 age-matched healthy subjects. We divided the stroke patients into two subgroups, those with visible occlusion and those with nonvisible occlusion having obstruction of the major cerebral artery.
The plasma levels of these three markers were significantly (p less than 0.01) higher in the stroke patients than in controls. Significant differences did not exist at any level between the patients and controls in the younger-aged subjects (less than or equal to 64 years of age), but did exist in the older-aged subjects (greater than or equal to 75 years of age). An age-related increase of the marker levels was noted between stroke patients and controls. No significant difference in the three markers was found among any of the stroke patients.
Increased levels of these markers in stroke patients seem to be related mostly to age.
我们研究了交联纤维蛋白降解产物的D - 二聚体、凝血酶 - 抗凝血酶III复合物以及纤溶酶 - α2 - 抗纤溶酶复合物的血浆水平，以检测缺血性中风患者的凝血系统激活情况，并确定年龄对这些标志物水平的可能影响。
我们测量了54例急性缺血性中风患者（中风发作后5天内）、44例慢性缺血性中风患者（发病3个月以上）以及50例年龄匹配的健康受试者的这三种标志物的血浆水平。我们将中风患者分为两个亚组，即主要脑动脉有可见闭塞的患者和无可见闭塞的患者。
中风患者的这三种标志物的血浆水平显著高于对照组（p < 0.01）。在年轻受试者（年龄≤64岁）中，患者与对照组在任何水平上均无显著差异，但在老年受试者（年龄≥75岁）中存在显著差异。在中风患者与对照组之间，观察到标志物水平随年龄增长而升高。在任何中风患者组中，这三种标志物均未发现显著差异。
中风患者中这些标志物水平的升高似乎主要与年龄有关。
