Nii A, Fujiwara K, Goto N
Safety Research Laboratories, Yamanouchi Pharmaceutical Co., Ltd., Japan.
J Vet Med Sci. 1991 Oct;53(5):847-54. doi: 10.1292/jvms.53.847.
Tyzzer's disease in rats carrying preneoplastic or neoplastic lesions in the liver was studied histopathologically and immunohistochemically. The formation of necrotic foci and the growth of organisms were detected within both glutathione S-transferase placental type (GST-P) positive preneoplastic or neoplastic hepatocyte areas and GST-P negative areas. However, plasma glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) values and number of necrotic foci of infected animals having preneoplastic lesions in the liver were smaller than those of infected animals receiving no carcinogenic procedure. These results suggest that the environment consisted of preneoplastic hepatocytes was unsuitable for the growth of organisms as compared with that of intact hepatocytes though the organism could grow within the preneoplastic hepatocytes.
对肝脏有癌前或肿瘤性病变的大鼠的泰泽氏病进行了组织病理学和免疫组织化学研究。在谷胱甘肽S-转移酶胎盘型（GST-P）阳性的癌前或肿瘤性肝细胞区域以及GST-P阴性区域内均检测到坏死灶的形成和病原体的生长。然而，肝脏有癌前病变的受感染动物的血浆谷草转氨酶（GOT）和谷丙转氨酶（GPT）值以及坏死灶数量均低于未接受致癌程序的受感染动物。这些结果表明，与完整肝细胞相比，由癌前肝细胞构成的环境虽然能使病原体在癌前肝细胞内生长，但并不适合病原体的生长。
