Singh M, Davenport A, Clatworthy I, Lewin J, Deroide F, Hubbard V, Rustin M H A
Department of Dermatology, The Royal Free Hospital, Pond Street, London NW3 2QG, UK.
Br J Dermatol. 2008 Jun;158(6):1358-62. doi: 10.1111/j.1365-2133.2008.08506.x. Epub 2008 Mar 20.
We originally reported four patients with nephrogenic systemic fibrosis (NSF) in the British Journal of Dermatology in 2003, and now present an update of their outcome. All four patients (three females and one male) presented within a six month period at our institution, and had received gadolinium contrast agents prior to disease onset. Two patients with functioning renal transplants had limited cutaneous disease, two patients maintained on haemodialysis had more severe disease and died one year after disease onset. Gadolinium deposition was demonstrated in lesional skin of one patient using electron microscopy and energy dispersive spectroscopy.
2003年，我们最初在《英国皮肤病学杂志》上报告了4例肾源性系统性纤维化（NSF）患者，现在介绍他们的最新病情。所有4例患者（3名女性和1名男性）均在我们机构就诊，就诊时间间隔为6个月，且在发病前均接受过钆对比剂。2例肾移植功能正常的患者皮肤病变较轻，2例维持血液透析的患者病情较重，发病1年后死亡。使用电子显微镜和能量色散光谱法在1例患者的病变皮肤中证实了钆沉积。
