Rashedi M, Maraud R, Audine M, Piet M, Castet M C
Laboratoire d'Histologie et Embryologie, Faculté de Médecine Paul-Broca, Université Bordeaux II, France.
C R Seances Soc Biol Fil. 1991;185(4):211-7.
Quail, or chick embryonic testes grafted respectively in the extraembryonic coelom of chick or quail embryos induce both a Mullerian duct regression and a masculinization of the female host gonads up to the differentiation of two testes, in some cases. Such a result confirms the fact evidenced previously in other bird species (chick and duck) that the testis-inducer is interspecific. Quail cells are not observed in histological sections of embryonic gonads of testis-grafted chicks. This allows to discard a possible influence of cells migrating from the graft to the host. The grafted testes act then through substance/s secreted in the blood stream. Present and previous experimental data strongly suggest that the same substance, i.e. the so-called anti-Mullerian hormone, is responsible for both MD regression and gonadal sex reversal.
将鹌鹑或鸡的胚胎睾丸分别移植到鸡或鹌鹑胚胎的胚外体腔中,在某些情况下会导致苗勒氏管退化,并且使雌性宿主性腺雄性化,直至分化出两个睾丸。这一结果证实了先前在其他鸟类物种(鸡和鸭)中所证明的事实,即睾丸诱导物是种间的。在移植睾丸的鸡胚胎性腺的组织切片中未观察到鹌鹑细胞。这使得我们可以排除从移植组织迁移到宿主的细胞可能产生的影响。移植的睾丸是通过分泌到血流中的物质起作用的。目前和先前的实验数据强烈表明,同一种物质,即所谓的抗苗勒氏激素,负责苗勒氏管退化和性腺性反转。