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家庭药柜与自我药疗:潜在健康威胁之源?

Home medication cabinets and self-medication: a source of potential health threats?

作者信息

De Bolle Leen, Mehuys Els, Adriaens Els, Remon Jean-Paul, Van Bortel Luc, Christiaens Thierry

机构信息

Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.

出版信息

Ann Pharmacother. 2008 Apr;42(4):572-9. doi: 10.1345/aph.1K533. Epub 2008 Mar 25.

Abstract

BACKGROUND

Data regarding the contents of home medication cabinets (HMCs), the management of leftover medications, and the inclination of patients toward self-initiated treatment using nonprescription drugs are scarce.

OBJECTIVE

To evaluate the nature and safety of medication storage and intended self-medication in a general population.

METHODS

A cross-sectional study was conducted in 72 Belgian community pharmacies. Pharmacy customers (N = 288, aged 18-80 y) were visited in their homes by pharmacy students. The HMCs were inventoried and the participants were interviewed.

RESULTS

A mean of 31 +/- 17 (range 6-136) drug packages were identified per household; in one-third of the cases, the packages were not stored safely. Prescription drugs accounted for 34% of the total. The most frequently encountered categories of registered medicines were nonopioid analgesics (7.2%), nonsteroidal antiinflammatory drugs (NSAIDs) (6.9%), nasal decongestants (3.5%) and antinausea agents (3.2%). Despite their high prevalence, NSAIDs and non-opioid analgesics did not predominate among the most frequently used drugs, whereas food supplements were used daily in 23.3% of households. Twenty-one percent of the drugs were expired, 9% were not stored in the original container, and the package insert was missing for 18%. Self-initiated treatment was considered for 56% of all drugs (over-the-counter drugs, 74%; prescription drugs, 21%). Indication, dosage, or treatment duration was misjudged by only 5.2% of the participants, but consulting the package insert was allowed. The tendency toward self-treatment decreased with age and with increasing number of medications taken daily (p = 0.002).

CONCLUSIONS

We found large amounts of drugs per household, with a high prevalence of analgesics and NSAIDs. Self-medication, although generally acceptable in terms of indication and dosage, was commonly practiced, also with prescription drugs. Taking into account that younger people showed a significantly higher intention of self-medication, a sustained awareness of the risks of self-medication is warranted for the future.

摘要

背景

关于家庭药柜(HMC)的药品内容、剩余药品的管理以及患者使用非处方药自行治疗的倾向的数据很少。

目的

评估普通人群中药物储存的性质和安全性以及预期的自我药疗情况。

方法

在72家比利时社区药房进行了一项横断面研究。药学专业学生到药房顾客(N = 288,年龄18 - 80岁)家中进行走访。对家庭药柜进行清点并对参与者进行访谈。

结果

每户平均发现31 ± 17(范围6 - 136)个药包;在三分之一的情况下,药包储存不安全。处方药占总数的34%。最常出现的注册药品类别为非阿片类镇痛药(7.2%)、非甾体抗炎药(NSAIDs)(6.9%)、鼻减充血剂(3.5%)和抗恶心药(3.2%)。尽管非甾体抗炎药和非阿片类镇痛药的使用率很高,但在最常用药物中并不占主导,而23.3%的家庭每天使用营养补充剂。21%的药物过期,9%未储存在原容器中,18%的药品说明书缺失。所有药物中有56%被考虑用于自行治疗(非处方药为74%;处方药为21%)。只有5.2%的参与者误判了适应证、剂量或治疗持续时间,但允许查阅药品说明书。自我治疗的倾向随着年龄增长和每日服用药物数量的增加而降低(p = 0.002)。

结论

我们发现每户有大量药物,镇痛药和非甾体抗炎药的使用率很高。自我药疗虽然在适应证和剂量方面总体上是可以接受的,但普遍存在,处方药也如此。考虑到年轻人自我药疗的意愿明显更高,未来有必要持续提高对自我药疗风险的认识。

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