Jelski Wojciech, Grochowska-Skiba Barbara, Szmitkowski Maciej
Zakład Diagnostyki Biochemicznej Akademii Medycznej w Białymstoku.
Postepy Hig Med Dosw (Online). 2007 Apr 24;61:226-30.
The human brain contains three classes of alcohol dehydrogenase (ADH) isoenzymes: classes I, III, and IV. These isoenzymes of ADH participate in the metabolism of many biological substances, such as retinol or serotonin. ADH is responsible for the metabolism of ethanol, but it has not been definitively demonstrated to play a significant role in the brain. Catalase and cytochrome P450 2E1 are distributed throughout the brain and these systems can oxidize ethanol to acetaldehyde. After incidental abuse of alcohol, it is metabolized mainly by ADH and catalase, but chronic alcohol consumption results in an increased the role of cytochrome P450 2E1.
人类大脑含有三类乙醇脱氢酶（ADH）同工酶：I类、III类和IV类。这些ADH同工酶参与许多生物物质的代谢，如视黄醇或血清素。ADH负责乙醇的代谢，但尚未明确证明其在大脑中发挥重要作用。过氧化氢酶和细胞色素P450 2E1分布于整个大脑，这些系统可将乙醇氧化为乙醛。偶尔滥用酒精后，其主要通过ADH和过氧化氢酶代谢，但长期饮酒会导致细胞色素P450 2E1的作用增强。
