Morovic Anamarija, Damjanov Ivan
Department of Pathology and Laboratory Medicine, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA.
Histol Histopathol. 2008 Jun;23(6):765-71. doi: 10.14670/HH-23.765.
Primary neuroectodermal tumors of the ovary are rare monophasic teratomas composed exclusively or almost exclusively of neuroectodemal tissue. Approximately 60 neuroectodermal tumors of the ovary have been reported in the literature. These tumors were classified as ependymoma, astrocytoma, glioblastoma multiforme, ependymoblastoma or as primitive neuroepithelial tumors such as medullo-blastoma, medulloepithelioma and neuroblastoma. Most tumors were diagnosed in the third and fourth decades of life, but occasionally they were first discovered in children, adolescents or older women. Microscopically, they are identical to equivalent neuroectodermal tumors of the central nervous system. The review of the literature shows that most patients with clinical stage I and II were treated surgically, whereas those with stage III or IV tumors received additional radiation or chemotherapy, or both. The clinical stage at the time of diagnosis is the most important prognostic parameter of these tumors.
卵巢原发性神经外胚层肿瘤是罕见的单相性畸胎瘤，完全或几乎完全由神经外胚层组织构成。文献中已报道了约60例卵巢神经外胚层肿瘤。这些肿瘤被分类为室管膜瘤、星形细胞瘤、多形性胶质母细胞瘤、室管膜母细胞瘤或原始神经上皮肿瘤，如髓母细胞瘤、髓上皮瘤和神经母细胞瘤。大多数肿瘤在第三和第四个十年被诊断出来，但偶尔也会在儿童、青少年或老年女性中首次发现。在显微镜下，它们与中枢神经系统的同类神经外胚层肿瘤相同。文献回顾表明，大多数临床I期和II期患者接受了手术治疗，而III期或IV期肿瘤患者则接受了额外的放疗或化疗，或两者兼而有之。诊断时的临床分期是这些肿瘤最重要的预后参数。
