Snell Gregory I, Levvey Bronwyn, Oto Takahiro, McEgan Robin, Mennan Mark, Eriksson Leif, Williams Trevor, Rosenfeldt Franklin
Lung Transplant Service, Alfred Hospital and Monash University, Melbourne, Victoria, Australia.
ANZ J Surg. 2008 Apr;78(4):262-5. doi: 10.1111/j.1445-2197.2008.04432.x.
For donation after cardiac death (DCD) transplantation to achieve its full potential, multiorgan retrieval is desirable. Although there are several novel individual techniques recently described for DCD lung donation, they have not been evaluated or compared in a DCD multiorgan scenario.
This study describes (i) the technical aspects and (ii) early lung and abdominal organ performance of several combinations of DCD donor liver, kidney and lung retrieval techniques that would mimic common DCD clinical scenarios.
Lung oxygenation, urine production, bile production and biochemical measures were assessed as the outcome of a complex ex vivo lung, liver and kidney perfusion DCD model.
Successful ex vivo multiorgan perfusion was possible following the three retrieval techniques tested, with excellent oxygenation over a 2-h assessment period, identical to prior studies where the lungs were tested alone. Multiorgan DCD retrieval, including lungs of good quality, is possible from a variety of clinical scenarios and should therefore be considered with all DCD retrieval opportunities.
为使心脏死亡后捐赠（DCD）移植发挥其最大潜力，多器官获取是可取的。尽管最近描述了几种用于DCD肺捐赠的新型个体技术，但它们尚未在DCD多器官情况下进行评估或比较。
本研究描述了（i）技术方面以及（ii）几种DCD供体肝脏、肾脏和肺获取技术组合的早期肺和腹部器官性能，这些组合模拟了常见的DCD临床情况。
评估肺氧合、尿量、胆汁生成和生化指标，作为复杂的离体肺、肝和肾灌注DCD模型的结果。
在所测试的三种获取技术之后，成功进行离体多器官灌注是可能的，在2小时的评估期内氧合良好，与之前单独测试肺的研究相同。从各种临床情况中获取包括优质肺在内的多器官DCD是可能的，因此应在所有DCD获取机会中予以考虑。
