Peng Jun, Li Yuan-Jian
Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China.
Eur J Pharmacol. 2008 May 31;586(1-3):9-13. doi: 10.1016/j.ejphar.2008.02.039. Epub 2008 Mar 4.
It has been shown that calcitonin gene-relate peptide plays an extensive role in cardiovascular system. CGRP is a potent vasodilator and plays an important role in mediation of nitroglycerin-induced vascular relaxation. Recently, calcitonin gene-relate peptide is emerging as a potential player in nitroglycerin tolerance. There is increasing evidence that the decreased depressor effect of nitroglycerin in tolerant states is closely related to a decrease in calcitonin gene-relate peptide release. The reduced release of calcitonin gene-relate peptide in nitroglycerin tolerance is associated with the decreased nitroglycerin biotransformation due to the mitochondrial dysfunction. Recent work has been shown that the inhibited activity of mitochondrial isoform of aldehyde dehydrogenase and the upregulation of phosphodiesterase 1A1 are the key factors that lead to the decreased nitroglycerin biotransformation in nitroglycerin tolerance, with a subsequently reduced release of calcitonin gene-relate peptide.
研究表明，降钙素基因相关肽在心血管系统中发挥着广泛作用。降钙素基因相关肽是一种强效血管舒张剂，在介导硝酸甘油诱导的血管舒张中起重要作用。最近，降钙素基因相关肽正成为硝酸甘油耐受性中的一个潜在因素。越来越多的证据表明，硝酸甘油在耐受状态下降压作用减弱与降钙素基因相关肽释放减少密切相关。硝酸甘油耐受性下降时降钙素基因相关肽释放减少与线粒体功能障碍导致的硝酸甘油生物转化减少有关。最近的研究表明，醛脱氢酶线粒体同工型活性受抑制和磷酸二酯酶1A1上调是导致硝酸甘油耐受性中硝酸甘油生物转化减少的关键因素，随后降钙素基因相关肽释放减少。
