Garrido N, Martínez-Conejero J A, Jauregui J, Horcajadas J A, Simón C, Remohí J, Meseguer M
Instituto Valenciano de Infertilidad, Universidad de Valencia, Valencia, Spain.
Fertil Steril. 2009 Apr;91(4 Suppl):1307-10. doi: 10.1016/j.fertnstert.2008.01.078. Epub 2008 Mar 25.
Sperm analysis following World Health Organization guidelines is unable to explain the molecular causes of male infertility when basic sperm parameters are within a normal range and women do not present gynecologic pathology. Consequently, there is a need for accurate diagnostic tools in this area, and microarray technology emerges as promising. We present, for the first time, preliminary results of a comparison of sperm mRNA expression profiles between fertile and infertile men with normal semen parameters, discovering profound discrepancies between groups, with potential diagnostic and therapeutic possibilities.
按照世界卫生组织的指南进行精子分析时，如果基本精子参数在正常范围内且女性不存在妇科病理问题，就无法解释男性不育的分子原因。因此，这一领域需要准确的诊断工具，而微阵列技术显得很有前景。我们首次展示了精液参数正常的 fertile 和 infertile 男性之间精子 mRNA 表达谱比较的初步结果，发现两组之间存在显著差异，具有潜在的诊断和治疗可能性。 （注：原文中“fertile”和“infertile”在医学语境下通常分别表示“可育的”和“不育的”，这里根据语境进行了翻译，但“fertile”在该语境下表述稍显突兀，或许原文此处有更准确的表述或背景信息缺失。）
