Soylu Ozlem Bekem, Ozturk Yesim, Ozer Erdener
Pediatric Gastroenterology, Hepatology, and Nutrition Unit, Department of Pediatrics, Dokuz Eylul University, Izmir, Turkey.
J Pediatr Gastroenterol Nutr. 2008 Apr;46(4):474-7. doi: 10.1097/MPG.0b013e31815a9923.
In this study, we evaluated the expression of alpha-defensin and its correlation with histological criteria in children with and without Helicobacter pylori-associated gastritis. Forty-five children were included. Immunohistochemical staining was performed and the relationship between alpha-defensin immunoscoring and H. pylori status and histological criteria was evaluated. Expression of alpha-defensin was significantly higher in the H. pylori-positive group (P < 0.001) and it was significantly associated with higher grades of chronic inflammation and neutrophil density (P < 0.001 for both). Our data show that alpha-defensin expression is increased in H. pylori infection in childhood and is associated with inflammatory tissue damage.
在本研究中，我们评估了α-防御素在幽门螺杆菌相关性胃炎患儿和非幽门螺杆菌相关性胃炎患儿中的表达及其与组织学标准的相关性。共纳入45名儿童。进行了免疫组织化学染色，并评估了α-防御素免疫评分与幽门螺杆菌状态及组织学标准之间的关系。α-防御素在幽门螺杆菌阳性组中的表达显著更高（P < 0.001），且与更高等级的慢性炎症和中性粒细胞密度显著相关（两者P均 < 0.001）。我们的数据表明，儿童幽门螺杆菌感染时α-防御素表达增加，且与炎症组织损伤相关。
