Slamovits T L, Rosen C E, Suhrland M J
Department of Ophthalmology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York 10467.
J Clin Neuroophthalmol. 1991 Sep;11(3):158-61.
A 3 1/2-year-old girl with a diagnosis of common acute lymphoblastic leukemia antigen (CALLA)-positive acute lymphoblastic leukemia was noted to be hypertensive and developed a tonic-clonic seizure. Computed tomography scan of the head revealed a right orbital mass. Orbital fine needle aspiration biopsy demonstrated rosette-like arrangements of cells with fibrillar cytoplasmic processes suggesting neuroblastoma. The tumor cells were antineuron-specific enolase positive. The cytologic findings suggested neuroblastoma, a diagnosis confirmed on subsequent work-up. The difficulty in distinguishing neuroblastoma from acute lymphoblastic leukemia in the pediatric patient is discussed in terms of clinical and cytologic features.
一名3岁半诊断为普通急性淋巴细胞白血病抗原（CALLA）阳性急性淋巴细胞白血病的女孩被发现患有高血压，并出现了强直阵挛性发作。头部计算机断层扫描显示右眼眶有一肿块。眼眶细针穿刺活检显示细胞呈玫瑰花结样排列，伴有纤维状胞质突起，提示为神经母细胞瘤。肿瘤细胞神经元特异性烯醇化酶呈阳性。细胞学检查结果提示为神经母细胞瘤，后续检查证实了这一诊断。本文从临床和细胞学特征方面讨论了小儿患者中神经母细胞瘤与急性淋巴细胞白血病鉴别诊断的困难。
