通过1,1 - 二乙氧基丁 - 2 - 烯与芳香腈反应制备的N - 金属化亚胺，作为合成取代嘧啶和环戊烯酮的有用中间体。
N-metalated imines by reaction of 1,1-diethoxybut-2-ene with aromatic nitriles, as useful intermediates for the synthesis of substituted pyrimidines and cyclopentenones.
作者信息
Blangetti Marco, Deagostino Annamaria, Prandi Cristina, Zavattaro Chiara, Venturello Paolo
机构信息
Dipartimento di Chimica Generale e Chimica Organica, Università di Torino, Via P. Giuria, 7, I-10125 Torino, Italy.
出版信息
Chem Commun (Camb). 2008 Apr 14(14):1689-91. doi: 10.1039/b719462e. Epub 2008 Feb 7.
DOI:10.1039/b719462e
PMID:18368166
Abstract
A new approach to the synthesis of pyrimidines and cyclopentenones is described. The method exploits the reactivity of alpha,beta-unsaturated acetals with aromatic nitriles in the presence of the Schlosser's superbase LIC-KOR.
摘要
描述了一种合成嘧啶和环戊烯酮的新方法。该方法利用了α,β-不饱和缩醛在施洛瑟超强碱LIC-KOR存在下与芳腈的反应活性。
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