Brenner H
Div. of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany.
Z Gastroenterol. 2008 Apr;46 Suppl 1:S20-2. doi: 10.1055/s-2007-963481.
Epidemiological evidence suggests that incidence of colorectal cancer can be reduced by 60-90% among participants of preventive colonoscopy with removal of precancerous lesions. Even with sigmoidoscopy, the majority of cancers can be prevented. Cost-effectiveness analyses suggest screening schemes based on colonoscopy every 10 years or on sigmoidoscopy every 5 years to be highly cost effective compared to other preventive measures. Even higher cost-effectiveness is to be expected if screening intervals can be extended to 20 or more years, as suggested by recent epidemiological evidence.
流行病学证据表明,在进行预防性结肠镜检查并切除癌前病变的参与者中,结直肠癌的发病率可降低60-90%。即使是乙状结肠镜检查,大多数癌症也可以预防。成本效益分析表明,与其他预防措施相比,每10年进行一次结肠镜检查或每5年进行一次乙状结肠镜检查的筛查方案具有很高的成本效益。如果像最近的流行病学证据所表明的那样,筛查间隔可以延长到20年或更长时间,预计成本效益会更高。