Lundervold A J, Reinvang I
Department of Psychosomatic and Behavioural Medicine, National Hospital, Oslo, Norway.
Scand J Psychol. 1991;32(3):275-83. doi: 10.1111/j.1467-9450.1991.tb00877.x.
Twenty patients with Huntington's disease (HD) and a comparison group were studied by a depression scale (MADRS) and a neuropsychological test-battery assessing central areas of cognitive function. The main purpose was to analyze the consistency of findings across patients and focus on the role of specific factors in the impairments. The HD-patients are impaired relative to norms and the comparison-group in all areas but verbal conceptual function. We further divided the HD-patients into subgroups according to severity of neuropsychological impairment. The groups generally show a pattern of increasing deficits. Early changes are found in tests of cognitive efficiency, memory and sensomotor function, but the pattern of impairment is variable. The more severely affected subgroups show an increased decline in performance and progressive involvement of a broader range of functions. The pattern of depressive symptoms in HD-patients indicates that cognitive symptoms of concentration difficulties and lassitude are prominent in all subgroups.
我们使用抑郁量表（蒙哥马利-阿斯伯格抑郁评定量表）和一组评估认知功能核心区域的神经心理学测试，对20名亨廷顿舞蹈症（HD）患者及一个对照组进行了研究。主要目的是分析不同患者研究结果的一致性，并关注特定因素在损伤中的作用。与常模及对照组相比，HD患者在除言语概念功能外的所有领域均存在损伤。我们还根据神经心理学损伤的严重程度将HD患者分为亚组。这些组通常呈现出缺陷增加的模式。在认知效率、记忆和感觉运动功能测试中发现了早期变化，但损伤模式是可变的。受影响更严重的亚组表现出成绩下降加剧以及更多功能的逐渐受累。HD患者的抑郁症状模式表明，注意力不集中和倦怠等认知症状在所有亚组中都很突出。
