Margulies K B, Hildebrand F L, Heublein D M, Burnett J C
Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905.
J Am Soc Nephrol. 1991 Nov;2(5):1041-5. doi: 10.1681/ASN.V251041.
Recent studies indicate that endothelin (ET), a potent endogenous systemic and renal vasoconstrictor peptide, may mediate decreases in GFR in models of acute renal dysfunction. Moreover, in an animal model of radiocontrast-induced nephropathy (RCIN), it was recently demonstrated that early renal hemodynamic responses to radiocontrast are attenuated by intra-arterial atrial natriuretic factor (ANF), which prevents subsequent RCIN. The studies presented here were therefore designed to determine whether i.v. infusion of radiocontrast produces increases in endogenous plasma and urinary ET and whether these responses are modulated by intra-arterial ANF in an animal model of RCIN. In these studies, dogs with pacing-induced heart failure received i.v. radiocontrast in the presence and absence of an intra-aortic infusion of ANF. Significant increases in both plasma and urinary ET were observed during and after radiocontrast. Although coadministration of ANF did not prevent increases in plasma and urinary ET, ANF preserved renal function acutely in this model of RCIN by increasing GFR above baseline levels.
近期研究表明，内皮素（ET）是一种强大的内源性全身及肾血管收缩肽，在急性肾功能障碍模型中可能介导肾小球滤过率（GFR）降低。此外，在放射性造影剂诱导的肾病（RCIN）动物模型中，最近有研究表明，动脉内注射心房利钠因子（ANF）可减弱对放射性造影剂的早期肾血流动力学反应，从而预防随后的RCIN。因此，本文开展的研究旨在确定静脉注射放射性造影剂是否会使内源性血浆和尿液ET增加，以及在RCIN动物模型中，这些反应是否会受到动脉内ANF的调节。在这些研究中，患有起搏诱导性心力衰竭的犬在有或没有主动脉内输注ANF的情况下接受静脉注射放射性造影剂。在注射放射性造影剂期间及之后，观察到血浆和尿液ET均显著增加。虽然同时给予ANF并不能阻止血浆和尿液ET的增加，但在该RCIN模型中，ANF通过使GFR高于基线水平而急性保护了肾功能。
