药物递送概述及电穿孔的替代方法。

Overview of drug delivery and alternative methods to electroporation.

作者信息

Hui Sek-Wen

机构信息

Cancer Biology Department, Roswell Park Cancer Institute, University at Buffalo, Buffalo, NY, USA.

出版信息

Methods Mol Biol. 2008;423:91-107. doi: 10.1007/978-1-59745-194-9_6.

DOI:10.1007/978-1-59745-194-9_6

PMID:18370192

Abstract

This chapter provides an overview of the application of electroporation to areas other than gene delivery. These areas include the delivery of drugs and vaccines to tissues and tumors as well as into and through the skin. Achievements and limitations of electroporation in these areas are presented. Alternative physical methods for gene and drug delivery besides electroporation are described. The advantages and drawbacks of electroporation, compared with these methods, are also discussed.

摘要

本章概述了电穿孔在基因传递以外领域的应用。这些领域包括将药物和疫苗递送至组织和肿瘤以及递送至皮肤内并透过皮肤。介绍了电穿孔在这些领域的成果和局限性。描述了除电穿孔外用于基因和药物传递的其他物理方法。还讨论了电穿孔与这些方法相比的优缺点。